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KMID : 0370219870310050253
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Yakhak Hoeji
1987 Volume.31 No. 5 p.253 ~ p.265
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Studies on Production of Monoclonal Antibodies Reactive with T-Cell Leukemia
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서병석/Seo BS
김원배/최응칠/김병각/Kim WB/Choi EC/Kim BK
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Abstract
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To develop hybridomas secreting monoclonal antibodies to be used as unlimited sources of reagents indispensable for the diagnosis and treatment of leukemic malignancy, a monoclonal antibody was generated to human pre-T leukemia cells (Jurkat). Hybridomas were produced against Jurkat cell line by fusing spleen cells from hyperimmunized mice with murine plasmacytoma cells (P3 X 63Ag8.V653). One monoclonal antibody derived from this fusion, designated DMJ-2 was reactive with T-cell lines (Jurkat, Molt-4 and RPMI-8402) and normal peripheral E-rosette forming T cells, but unreactive with B-cell lines (Daudi, Nalm-6) and non-T, non-B cell line (K562). Conclusively DMJ-2 was reactive with mature and immature T-lineage lymphoid cells.
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KEYWORD
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